Fig. 1

Bacterial composition estimated from 16S rRNA reads. a The bar charts present the bacterial composition assigned with the HOMD at the genus level, shown as the relative abundance. Each color corresponds to the genus indicated on the right side. b First coordinates in the PCoA for the bacterial composition assigned with the HOMD are plotted with second coordinates in the scatter graph. The CLP and control participants are indicated by red and blue, respectively. c The dissimilarity matrix is derived from Spearman’s rank correlation coefficient between any two participants and is used to construct a dendrogram of hierarchical clustering. A heat map of log2 rc-rRNA abundances is shown below the dendrogram