Fig. 2

Saliva protein expression after fixed orthodontic apparatus placement. A Left panel shows proteins expressed in the control samples, which include pre-placement sample pools (n = 12), and control samples (n = 6) (no orthodontic therapy). The center panel presents proteins expressed in the early and lag phase of the OTM, which includes post placement (0 h), as well as two and then seven days post therapy (n = 12). The right panel shows proteins expressed in the post-lag phase of OTM at 30 days post placement when bone remodeling occurs (n = 12). Proteins are grouped according to the physiological processes they are part of. B Proteins interaction network related to saliva BMP4 in the post-lag phase, as predicted by STITCH software, version 5.0 (http://stitch.embl.de). Line thickness indicates strength of data support. BMP4 - bone morphogenetic protein 4; BMPER - BMP-binding endothelial regulator protein; FGF5 - fibroblast growth factor 5; IGFBP3 - insulin-like growth factor-binding protein 3; CKAP4 - cytoskeleton-associated protein 4; MYC - myc proto-oncogene protein