miRNAs | Response to MF | Direct gene targets | Pathway(s) regulated | Role in bone remodeling | References |
---|---|---|---|---|---|
miR-34a | hMSCs, CS↑ | LDHA↓ | Cellular anaerobic glycolysis↓ | Inhibit OB differentiation | [59] |
hBMSCs | DKK1↓ | Wnt↓ | Inhibit OB differentiation | [60] | |
MC3T3-E1, FSS↓ | FGFR1 | Runx2↓ | Inhibit OB proliferation and promote apoptosis | [61] | |
hMSCs | JAG1 | Notch signaling↓ | Inhibit OB differentiation and proliferation | [62] | |
miR-103 | hFOB1.19, CS↓ | Runx2 | Runx2↓ | Inhibit OB proliferation | [63] |
miR-139-5p | mOB, CS↓ | MACF1↓ | Wnt/β-catenin or BMP↓ | Inhibit OB differentiation | [64] |
miR-33-5p | MC3T3-E1, CS↓ FSS↑ | Hmga2↓ | Extensive regulation | Attenuated the inhibition of OB differentiation induced by Hmga2 | |
miR-1246 | PDLSCs, CS↑ | GSK3β, Axin2 | Wnt/β-catenin↑ | Promote OB differentiation | |
miR-503-5p | BMSCs, CS↓ | SORBS1 | Unknown | Inhibit OB differentiation and proliferation | |
miR-494-3p | MC3T3-E1, CF↑ | FGFR2、 ROCK1↓ | FGF | Inhibit OB proliferation | [70] |
miR-195-5p | PDLCs, CS↓ | WNT3A BMPR1A FGF2 | WNT, FGF, BMP↓ | Inhibit osteogenic differentiation of PDLCs | |
miR-424-5p | PDLCs, CS↓ | WIF1 | Wnt/β-catenin↓ | Inhibit osteogenic differentiation of PDLCs | |
miR-145-5p | PDLCs, CS↓ | SEMA3A | Wnt/β-catenin↓ | Inhibit osteogenic differentiation of PDLCs | |
miR-3198 | PDL, CS↓CF↑ | Unknown | OPG↓ | Inhibit osteoclastogenesis | [75] |
miR-21 | mPDLSC, Orthodontic force↑ | PDCD-4↓ | Unknown | Attenuate the repression of PDCD-4 to OC differentiation | [76] |
PDLSC, CS↑ | ACVR 2B | TGF-β pathway↑ | Promote stretch-induced PDLSC osteogenesis | [77] | |
hUMSCs | PI3K-AKT-GSK3β | β-catenin/RUNX-2↑ | Promote osteogenesis of MSCs | [78] | |
MC3T3-E1 | Smad 5 | BMP, TGF-β ↑ | Promote the level of OB differentiation and matrix mineralization | [79] | |
BMSCs | Smad 7 | Smad7-Smad1/5/8-Runx2 pathway↑ | Promote the bone formation of BMSCs | [80] | |
PDLSC | HIF-1 | VEGF | Promote PDLSC osteogenesis | ||
mOB | FasL | Fas-FasL | Promote osteoclastogenesis and suppress osteoclastic apoptosis | [83] | |
miR-29 family (a,b,c) | PDLCs, CS↓ CF↑ | COL1A1 COL3A1 COL5A1↓ | Unknown | Unknown | [84] |
OC | Calcr↓ | Calcr-cAMP-Ctsk↑ | Promote bone resorption | [85] | |
RAW264.7 | Cdc42, Srgap2, Gpr85 Cd93 Nfia | Extensive regulation | Promote the differentiation and function of OC | [86] |