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Table 1 Biological approaches to enhance tooth movement

From: Acceleration of tooth movement during orthodontic treatment - a frontier in Orthodontics

Authors Biological molecules tested Animal or humans Duration Acceleration
Saito et al. [9] PGs and IL-1 Cats Weeks Yes
Yamasaki et al. [10] PGs Rats Weeks Yes
Yamasaki et al. [11] PGs Monkeys Weeks Yes
Leiker et al. [7] PGs Rats Weeks Yes
Yamasaki et al. [12] PGs Human Months Yes
Seifi et al. [13] PGs + Ca Rats Weeks Yes and stabilize root resorption
Seifi et al. [13] PGs − Ca Rats Weeks Yes
Kanzaki et al. [14] RANKL/RANK Animals Weeks Yes
OPG Animals Weeks Yes
Nishijima et al. [15] RANKL/RANK/OPG and root resorption Human Months Relation with root resorption
Collins et al. [16] Vitamin D Cats Weeks Yes
Kale et al. [17] Vitamin D and PGs Rats Weeks Yes
Soma et al. [18] PTH Rats Weeks Yes
Soma et al. [19] PTH Rats Weeks Yes
Liu Zi et al. [20] Relaxin Rats Weeks Yes
Madan et al. [21] Relaxin Rats Weeks Effect on collage fibers
Mcgorray et al. [22] Relaxin Human Weeks No
  1. PGs, prostaglandins; RANKL, receptor activator of nuclear factor kappa B ligand; PTH, parathyroid hormone; Ca ,Calcium.