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Table 1 Biological approaches to enhance tooth movement

From: Acceleration of tooth movement during orthodontic treatment - a frontier in Orthodontics

Authors

Biological molecules tested

Animal or humans

Duration

Acceleration

Saito et al. [9]

PGs and IL-1

Cats

Weeks

Yes

Yamasaki et al. [10]

PGs

Rats

Weeks

Yes

Yamasaki et al. [11]

PGs

Monkeys

Weeks

Yes

Leiker et al. [7]

PGs

Rats

Weeks

Yes

Yamasaki et al. [12]

PGs

Human

Months

Yes

Seifi et al. [13]

PGs + Ca

Rats

Weeks

Yes and stabilize root resorption

Seifi et al. [13]

PGs − Ca

Rats

Weeks

Yes

Kanzaki et al. [14]

RANKL/RANK

Animals

Weeks

Yes

OPG

Animals

Weeks

Yes

Nishijima et al. [15]

RANKL/RANK/OPG and root resorption

Human

Months

Relation with root resorption

Collins et al. [16]

Vitamin D

Cats

Weeks

Yes

Kale et al. [17]

Vitamin D and PGs

Rats

Weeks

Yes

Soma et al. [18]

PTH

Rats

Weeks

Yes

Soma et al. [19]

PTH

Rats

Weeks

Yes

Liu Zi et al. [20]

Relaxin

Rats

Weeks

Yes

Madan et al. [21]

Relaxin

Rats

Weeks

Effect on collage fibers

Mcgorray et al. [22]

Relaxin

Human

Weeks

No

  1. PGs, prostaglandins; RANKL, receptor activator of nuclear factor kappa B ligand; PTH, parathyroid hormone; Ca ,Calcium.