Table 1 Factors affecting the expression and regulation of osteopontin
From: Role of osteopontin in bone remodeling and orthodontic tooth movement: a review
Expression and upregulation of OPN | Downregulation of OPN |
|---|---|
Transcription factors—Runx2 and Osterix [68] | cGMP-dependent protein kinase [2] |
Inorganic phosphate [69] | Bisphosphonates [2] |
Systematic conditions—hypophosphatemia, hypocalcemia [2] Hormones—glucocorticoids, [70] | ERK inhibitor |
Vitamins—retinoic acid [70] |  |
Inflammatory mediators—TNFα, IL-1β, TGFβ [14] |  |
Mechanical stress | Â |