Association between polymorphisms in genes encoding estrogen receptors (ESR1 and ESR2) and excreted bisphenol A levels after orthodontic bracket bonding: a preliminary study

Progress in Orthodontics

Table 1 Single-nucleotide polymorphisms studied

Gene	Locus	Reference sequence	Type of alteration	Base change (context sequence)	Global MAF
ESR1	6q25.1	rs2234693	Intron variant	AGC[C/T]GTT	0.4463/2235
ESR2	14q23.2	rs4986938	Intron variant, non-coding transcript variant, UTR variant 3 prime	AGC[C/T]TGT	0.2598/1301
ESR2	14q23.2	rs1256049	Intron variant, non-coding transcript variant, synonymous codon	CCG[C/T]ACT	0.1296/649

Source of information: dbSNP from: https://www.ncbi.nlh.nih.gov/snp/; http://genome.uscs.edu/; and, https://www.thermofisher.com
Bold indicates lower frequency allele