Study | Setting | Total sample recruited | Mean age (years) | Study groups (n) | Outcomes | Reference |
---|---|---|---|---|---|---|
Dickinson 2008 | University of California, Los Angeles Medical Center and Olive view Medical Center | 21: male 9, female 12 | 16.1 | Intervention group: the InFuse® bone graft (Sofamor-Danek, Memphis, Tennessee), which is a collagen matrix impregnated with rhBMP-2, were grafted (9) Control group: traditional iliac crest graft (12) | Alveolar ridge healing (preoperative, 6 weeks and 1 year after surgery); three-dimensional computed tomographic scan results (preoperative and 1 year after surgery); volume of bone filled in alveolar cleft (preoperative, 6 weeks and 1 year after surgery); length of hospital stay; donor site pain intensity and frequency (VAS) (day 1, day 7, week 3, week 6, month 3; cost of surgery) | [25] |
Alonso 2010 | Craniofacial Surgery Unit of the University of Sao Paulo Medical School and CAIF (Assistance Center for Cleft Lip and Palate) | 16: male 9, female 7 | 9.6 | Intervention group: InFuse® bone graft (Medtronic, Memphis, Tennessee), a collagen sponge carrier with lyophilized rhBMP-2 (8) Control group: traditional iliac crest graft (8) | Three-dimensional computed tomographic scan results (preoperative, 6 months and 12 months after surgery); volume of bone filled in alveolar cleft (preoperative, 6 weeks and 1 year after surgery); donor site pain intensity and frequency (VAS) (day 1, day 7, week 3, week 6, month 3) | [26] |
Canan 2012 | University of Sao Paulo Medical School, Brazil | 18: male 12, female 6 | From 8 to 15 | Intervention group: the InFuse® bone graft (Medtronic, Memphis, Tennessee), which is an absorbable collagen sponge with rhBMP-2, were grafted (6) Control group: traditional iliac crest graft (6) Periosteoplasty group: (6) | Three-dimensional computed tomographic scan results (preoperative, 3 months, 6 months, and 12 months after surgery); volume of bone filled in alveolar cleft (preoperative, 3 months, 6 months and 12 months after surgery); maxillary height repair (preoperative, 3 months, 6 months, and 12 months after surgery) | [4] |
Neovius 2013 | Karolinska University Hospital, Stockholm Craniofacial Centre, Sweden | 7: male 6, female 1 | 9.11 | Intervention group: rhBMP-2 delivered by an hydrogel carrier was grafted (4) Control group: traditional iliac crest graft (3) | Three-dimensional computed tomographic scan results (preoperative, 6 months after surgery); volume of bone filled in alveolar cleft (preoperative, 6 months after surgery); length of hospital stay; donor site morbidity; surgery time | [27] |