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Table 2 Characteristics of included studies

From: Secondary alveolar bone grafting using autologous versus alloplastic material in the treatment of cleft lip and palate patients: systematic review and meta-analysis

Study

Setting

Total sample recruited

Mean age (years)

Study groups (n)

Outcomes

Reference

Dickinson 2008

University of California, Los Angeles Medical Center and Olive view Medical Center

21: male 9, female 12

16.1

Intervention group: the InFuse® bone graft (Sofamor-Danek, Memphis, Tennessee), which is a collagen matrix impregnated with rhBMP-2, were grafted (9)

Control group: traditional iliac crest graft (12)

Alveolar ridge healing (preoperative, 6 weeks and 1 year after surgery); three-dimensional computed tomographic scan results (preoperative and 1 year after surgery); volume of bone filled in alveolar cleft (preoperative, 6 weeks and 1 year after surgery); length of hospital stay; donor site pain intensity and frequency (VAS) (day 1, day 7, week 3, week 6, month 3; cost of surgery)

[25]

Alonso 2010

Craniofacial Surgery Unit of the University of Sao Paulo Medical School and CAIF (Assistance Center for Cleft Lip and Palate)

16: male 9, female 7

9.6

Intervention group: InFuse® bone graft (Medtronic, Memphis, Tennessee), a collagen sponge carrier with lyophilized rhBMP-2 (8)

Control group: traditional iliac crest graft (8)

Three-dimensional computed tomographic scan results (preoperative, 6 months and 12 months after surgery); volume of bone filled in alveolar cleft (preoperative, 6 weeks and 1 year after surgery); donor site pain intensity and frequency (VAS) (day 1, day 7, week 3, week 6, month 3)

[26]

Canan 2012

University of Sao Paulo Medical School, Brazil

18: male 12, female 6

From 8 to 15

Intervention group: the InFuse® bone graft (Medtronic, Memphis, Tennessee), which is an absorbable collagen sponge with rhBMP-2, were grafted (6)

Control group: traditional iliac crest graft (6)

Periosteoplasty group: (6)

Three-dimensional computed tomographic scan results (preoperative, 3 months, 6 months, and 12 months after surgery); volume of bone filled in alveolar cleft (preoperative, 3 months, 6 months and 12 months after surgery); maxillary height repair (preoperative, 3 months, 6 months, and 12 months after surgery)

[4]

Neovius 2013

Karolinska University Hospital, Stockholm Craniofacial Centre, Sweden

7: male 6, female 1

9.11

Intervention group: rhBMP-2 delivered by an hydrogel carrier was grafted (4)

Control group: traditional iliac crest graft (3)

Three-dimensional computed tomographic scan results (preoperative, 6 months after surgery); volume of bone filled in alveolar cleft (preoperative, 6 months after surgery); length of hospital stay; donor site morbidity; surgery time

[27]