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Table 2 Characteristics of included studies

From: Secondary alveolar bone grafting using autologous versus alloplastic material in the treatment of cleft lip and palate patients: systematic review and meta-analysis

Study Setting Total sample recruited Mean age (years) Study groups (n) Outcomes Reference
Dickinson 2008 University of California, Los Angeles Medical Center and Olive view Medical Center 21: male 9, female 12 16.1 Intervention group: the InFuse® bone graft (Sofamor-Danek, Memphis, Tennessee), which is a collagen matrix impregnated with rhBMP-2, were grafted (9) Control group: traditional iliac crest graft (12) Alveolar ridge healing (preoperative, 6 weeks and 1 year after surgery); three-dimensional computed tomographic scan results (preoperative and 1 year after surgery); volume of bone filled in alveolar cleft (preoperative, 6 weeks and 1 year after surgery); length of hospital stay; donor site pain intensity and frequency (VAS) (day 1, day 7, week 3, week 6, month 3; cost of surgery) [25]
Alonso 2010 Craniofacial Surgery Unit of the University of Sao Paulo Medical School and CAIF (Assistance Center for Cleft Lip and Palate) 16: male 9, female 7 9.6 Intervention group: InFuse® bone graft (Medtronic, Memphis, Tennessee), a collagen sponge carrier with lyophilized rhBMP-2 (8) Control group: traditional iliac crest graft (8) Three-dimensional computed tomographic scan results (preoperative, 6 months and 12 months after surgery); volume of bone filled in alveolar cleft (preoperative, 6 weeks and 1 year after surgery); donor site pain intensity and frequency (VAS) (day 1, day 7, week 3, week 6, month 3) [26]
Canan 2012 University of Sao Paulo Medical School, Brazil 18: male 12, female 6 From 8 to 15 Intervention group: the InFuse® bone graft (Medtronic, Memphis, Tennessee), which is an absorbable collagen sponge with rhBMP-2, were grafted (6) Control group: traditional iliac crest graft (6) Periosteoplasty group: (6) Three-dimensional computed tomographic scan results (preoperative, 3 months, 6 months, and 12 months after surgery); volume of bone filled in alveolar cleft (preoperative, 3 months, 6 months and 12 months after surgery); maxillary height repair (preoperative, 3 months, 6 months, and 12 months after surgery) [4]
Neovius 2013 Karolinska University Hospital, Stockholm Craniofacial Centre, Sweden 7: male 6, female 1 9.11 Intervention group: rhBMP-2 delivered by an hydrogel carrier was grafted (4) Control group: traditional iliac crest graft (3) Three-dimensional computed tomographic scan results (preoperative, 6 months after surgery); volume of bone filled in alveolar cleft (preoperative, 6 months after surgery); length of hospital stay; donor site morbidity; surgery time [27]