Table 3 Genotype and allele distribution among class I, class II and class III skeletal malocclusions
From: Association between craniofacial morphological patterns and tooth agenesis-related genes
Genetic polymorphism | Genotypes, n (%) | p value | Alleles, n (%) | p value | |||
|---|---|---|---|---|---|---|---|
MSX1rs1042484 | AA | AG | GG | A | G | ||
Class I | 118 (69.8) | 38 (22.5) | 13 (7.7) | Reference | 274 (81.1) | 64 (18.9) | Reference |
Class II | 106 (71.1) | 29 (19.5) | 14 (9.4) | 0.730 | 241 (80.9) | 57 (19.1) | 0.999 |
Class III | 26 (70.3) | 8 (21.6) | 3 (8.1) | 0.990 | 60 (81.1) | 14 (18.9) | 0.863 |
PAX9rs8004560 | AA | AG | GG | A | G | ||
Class I | 91 (62.3) | 35 (24.0) | 20 (13.7) | Reference | 217 (74.3) | 75 (25.7) | Reference |
Class II | 100 (67.1) | 39 (26.2) | 10 (6.7) | 0.140 | 239 (80.2) | 59 (19.8) | 0.108 |
Class III | 25 (62.5) | 10 (25.0) | 5 (12.5) | 0.975 | 60 (75.0) | 20 (25.0) | 0.999 |
TGFα1rs2902345 | CC | CT | TT | C | T | ||
Class I | 51 (28.5) | 89 (49.7) | 39 (21.8) | Reference | 191 (53.4) | 167 (46.6) | Reference |
Class II | 46 (28.8) | 77 (48.1) | 37 (23.1) | 0.947 | 169 (52.8) | 151 (47.2) | 0.999 |
Class III | 16 (37.2) | 22 (51.2) | 5 (11.6) | 0.261 | 54 (62.8) | 32 (37.2) | 0.144 |
FGF3rs1893047 | AA | AG | GG | A | G | ||
Class I | 157 (76.6) | 36 (17.6) | 12 (5.9) | Reference | 350 (85.4) | 60 (14.6) | Reference |
Class II | 165 (75.3) | 39 (17.8) | 15 (6.8) | 0.932 | 369 (84.2) | 69 (15.8) | 0.964 |
Class III | 28 (59.6) | 16 (34.0) | 3 (6.4) | 0.038* | 72 (76.6) | 22 (23.4) | 0.037* |
FGF10rs900379 | CC | CT | TT | C | T | ||
Class I | 70 (29.8) | 107 (45.5) | 58 (24.7) | Reference | 247 (52.6) | 223 (47.4) | Reference |
Class II | 72 (30.5) | 115 (48.7) | 49 (20.8) | 0.585 | 259 (54.9) | 213 (45.1) | 0.509 |
Class III | 19 (33.3) | 20 (35.1) | 18 (31.6) | 0.336 | 58 (50.9) | 56 (49.1) | 0.103 |
FGF13rs12838463 | AA | AG | GG | A | G | ||
Class I | 110 (47.8) | 65 (28.3) | 55 (23.9) | Reference | 285 (62.0) | 175 (38.0) | Reference |
Class II | 112 (46.9) | 60 (25.1) | 67 (28.0) | 0.541 | 284 (59.4) | 194 (40.6) | 0.765 |
Class III | 29 (50.9) | 14 (24.6) | 14 (24.6) | 0.850 | 72 (63.2) | 42 (36.8) | 0.876 |
FGF13rs5931572 | AA | AG | GG | A | G | ||
Class I | 72 (32.6) | 63 (28.5) | 86 (38.9) | Reference | 207 (46.8) | 235 (53.2) | Reference |
Class II | 67 (29.5) | 65 (28.6) | 95 (41.9) | 0.749 | 199 (43.8) | 255 (56.2) | 0.823 |
Class III | 16 (30.8) | 15 (28.8) | 21 (40.4) | 0.966 | 47 (45.2) | 57 (54.8) | 0.091 |
FGF13rs5974804 | AA | AG | GG | A | G | ||
Class I | 83 (42.1) | 50 (25.4) | 64 (32.5) | Reference | 216 (54.8) | 178 (45.2) | Reference |
Class II | 80 (44.7) | 48 (26.8) | 51 (28.5) | 0.897 | 208 (58.1) | 150 (41.9) | 0.820 |
Class III | 22 (46.8) | 9 (19.1) | 16 (34.0) | 0.678 | 53 (56.4) | 41 (43.6) | 0.784 |