Table 4 Genotype and allele distribution among mesofacial, dolichofacial, and brachyfacial growth patterns
From: Association between craniofacial morphological patterns and tooth agenesis-related genes
Genetic polymorphism | Genotypes, n (%) | p value | Alleles, n (%) | p value | |||
|---|---|---|---|---|---|---|---|
MSX1rs1042484 | AA | AG | GG | A | A | ||
Mesofacial | 119 (69.6) | 35 (20.5) | 17 (9.9) | Reference | 273 (79.8) | 69 (20.2) | Reference |
Dolichofacial | 77 (70.6) | 22 (20.2) | 10 (9.2) | 0.975 | 176 (80.7) | 42 (19.3) | 0.888 |
Brachyfacial | 54 (72.0) | 18 (24.0) | 3 (4.0) | 0.271 | 126 (84) | 24 (16) | 0.335 |
PAX9rs8004560 | AA | AG | GG | A | G | ||
Mesofacial | 103 (66.5) | 37 (23.9) | 15 (9.7) | Reference | 243 (78.4) | 67 (21.6) | Reference |
Dolichofacial | 70 (63.1) | 28 (25.2) | 13 (11.7) | 0.811 | 168 (75.7) | 54 (24.3) | 0.527 |
Brachyfacial | 43 (62.3) | 19 (27.5) | 7 (10.1) | 0.823 | 105 (76.1) | 33 (23.9) | 0.680 |
TGFα1rs2902345 | CC | CT | TT | C | T | ||
Mesofacial | 51 (27.4) | 95 (51.1) | 40 (21.5) | Reference | 197 (53.0) | 175 (47) | Reference |
Dolichofacial | 35 (30.2) | 55 (47.4) | 26 (22.4) | 0.815 | 125 (53.9) | 107 (46.1) | 0.888 |
Brachyfacial | 27 (33.8) | 38 (47.5) | 15 (18.8) | 0.574 | 92 (57.5) | 68 (42.5) | 0.383 |
FGF3rs1893047 | AA | AG | GG | A | G | ||
Mesofacial | 166 (75.1) | 39 (17.6) | 16 (7.2) | Reference | 371 (83.9) | 71 (16.1) | Reference |
Dolichofacial | 111 (75.5) | 28 (19.0) | 8 (5.4) | 0.765 | 250 (85.0) | 44 (15.0) | 0.865 |
Brachyfacial | 73 (70.9) | 24 (23.3) | 6 (5.8) | 0.464 | 170 (82.5) | 36 (17.5) | 0.886 |
FGF10rs900379 | CC | CT | TT | C | T | ||
Mesofacial | 78 (31.0) | 118 (46.8) | 56 (22.2) | Reference | 274 (54.4) | 230 (45.6) | Reference |
Dolichofacial | 49 (30.2) | 73 (45.1) | 40 (24.7) | 0.873 | 171 (52.8) | 153 (47.2) | 0.871 |
Brachyfacial | 34 (29.8) | 51 (44.7) | 29 (25.4) | 0.658 | 119 (52.2) | 109 (47.8) | 0.798 |
FGF13rs12838463 | |||||||
Mesofacial | 116 (47.0) | 63 (25.5) | 68 (27.5) | Reference | 295 (59.7) | 199 (40.3) | Reference |
Dolichofacial | 79 (47.6) | 43 (25.9) | 44 (26.5) | 0.911 | 201 (60.5) | 131 (39.5) | 0.981 |
Brachyfacial | 56 (49.6) | 33 (29.2) | 24 (21.2) | 0.624 | 145 (64.2) | 81 (35.8) | 0.678 |
FGF13rs5931572 | AA | AG | GG | A | G | ||
Mesofacial | 70 (29.2) | 69 (28.8) | 101 (42.1) | Reference | 209 (43.5) | 271 (56.5) | Reference |
Dolichofacial | 54 (35.3) | 40 (26.1) | 59 (38.6) | 0.443 | 148 (48.4) | 158 (51.6) | 0.746 |
Brachyfacial | 31 (29.0) | 34 (31.8) | 42 (39.3) | 0.830 | 96 (44.9) | 118 (55.1) | 0.104 |
FGF13rs5974804 | AA | AG | GG | A | G | ||
Mesofacial | 84 (42.6) | 49 (24.9) | 64 (32.5) | Reference | 217 (55.1) | 177 (44.9) | Reference |
Dolichofacial | 60 (46.9) | 33 (25.8) | 35 (27.3) | 0.602 | 153 (59.8) | 103 (40.2) | 0.139 |
Brachyfacial | 41 (41.8) | 25 (25.5) | 32 (32.7) | 0.989 | 107 (54.6) | 89 (45.4) | 0.912 |