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Table 3 GRADE evidence profile table about influence of heritability in main occlusal traits

From: Influence of heritability on occlusal traits: a systematic review of studies in twins

Certainty Assessment
No. of Studies Study design Risk of bias Inconsistency Indirectness Imprecision Other consideration Impact Overall certainty of evidence
Arch width
6 OSa Seriousb Not serious Not serious Not serious None Arch width has an important heritability component Low
Arch length
5 OSa Seriousb Not serious Not serious Not serious None Genetic determination can be demonstrated with a higher heritability coefficient for the maxillary arch than for the mandibular
Low
Overjet
6 OSa Seriousb Not serious Not serious Not serious None The heritability estimate for was not often mentioned, highlighting a strong environmental contribution to observed variation
Low
Overbite
6 OSa Seriousb Not serious Not serious Not serious None Heritability was weak for overbite, suggesting the presence of hidden environmental determinacies
Low
Malalignment/intertooth space
5 OSa Seriousb Not serious Not serious Not serious None The alignment of teeth, mainly in the mandibular arch, is under strong dominance of genetic factors
Low
Sagittal molar relationship
4 OSa Seriousb Not serious Not serious Not serious None It appears that the environmental component as the major determinant
Low
Posterior crossbite
4 OSa Seriousb Not serious Not serious Not serious None Although one study reports a high heritability value, most studies did not shown a genetic influence on this trait
Low
  1. aDown one level by study design, OS observational studies
  2. bBased on the bias of risk assessment tool
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