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Table 4 Summary of risk of bias assessment for non-randomized studies-ROBINS-1 tool

From: The effect of the local administration of biological substances on the rate of orthodontic tooth movement: a systematic review of human studies

Domain

Yamasaki et al. [27]

Spielmann et al. [25]

Patil et al. [40]

Ciur et al. [41]

Nemtoi et el [30].

Bias due to confounding

Serious

Serious

Moderate

Moderate

Moderate

Bias in selection of participants for the study

Serious

Moderate

Moderate

Moderate

Moderate

Bias in classification of interventions

Moderate

Low

Low

Low

Low

Bias in measurement of outcomes

Serious

Serious

Moderate

Moderate

Moderate

Bias in selection of the reported result

Moderate

Low

Low

Low

Low

Overall

Serious

Serious

Moderate

Moderate

Moderate