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Table 4 Summary of risk of bias assessment for non-randomized studies-ROBINS-1 tool

From: The effect of the local administration of biological substances on the rate of orthodontic tooth movement: a systematic review of human studies

Domain Yamasaki et al. [27] Spielmann et al. [25] Patil et al. [40] Ciur et al. [41] Nemtoi et el [30].
Bias due to confounding Serious Serious Moderate Moderate Moderate
Bias in selection of participants for the study Serious Moderate Moderate Moderate Moderate
Bias in classification of interventions Moderate Low Low Low Low
Bias in measurement of outcomes Serious Serious Moderate Moderate Moderate
Bias in selection of the reported result Moderate Low Low Low Low
Overall Serious Serious Moderate Moderate Moderate
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