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Table 5 Summary of risk of bias assessment for randomized studies—The Cochrane’s Collaboration’s tool

From: The effect of the local administration of biological substances on the rate of orthodontic tooth movement: a systematic review of human studies

Domain Al-Hasani et al. [26] McGorray et al. [28] Tehranchi et al. [31] Yussif et al. [42] Varughese et al. [43] El-Timamy et al. [32]
Randomization process High Some concerns Some concerns Some concerns Low Low
Deviations from intended interventions Some concerns Low Low Some concerns Low Low
Missing outcome data Low Low Some concerns Low Low Low
Measurement of the outcome Some concerns Low Low Unclear Some concerns Some concerns
Selection of the reported result Low Low Low Low Some concerns Low
overall Some concerns Low Some concerns Some concerns Low Low
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