The effect of the local administration of biological substances on the rate of orthodontic tooth movement: a systematic review of human studies

Progress in Orthodontics

Table 7 Quality of available evidence on the rate of orthodontic tooth movement for the RCT

Quality assessment						Effect	Quality
Studies	Risk of bias	Inconsistency	Indirectness	Imprecision	Other	Effect	Quality
Vit D
2	Serious^a	Not serious	Not serious	Not serious^a	None	Al-Hasani [26]: no effect Varughese [43]: increased in the EG	⨁⨁⨁◯^b Moderate
HRH
1	Not Serious	Not serious	Not serious	Not serious	None	No difference	⨁⨁⨁⨁ High
PRP
1	Not serious	Not serious	Not serious	Not serious	None	Tehranchi [31]: no effect El-Timamy [32]: no effect	⨁⨁⨁⨁ High
Vit C
1	Serious^a	Not serious	Not serious	not serious	None	Increased in the EG	⨁⨁⨁◯^b Moderate

EG experimental group, HRH human relaxin hormone, PRP platelet-rich plasma, Vit C vitamin C, Vit D vitamin D
^aThe results overall are based only on few studies
^bOwing to the lack of concealed allocation in the randomization, the respective grading of evidence started as moderate