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Table 7 Quality of available evidence on the rate of orthodontic tooth movement for the RCT

From: The effect of the local administration of biological substances on the rate of orthodontic tooth movement: a systematic review of human studies

Quality assessment Effect Quality
Studies Risk of bias Inconsistency Indirectness Imprecision Other
Vit D
 2 Seriousa Not serious Not serious Not seriousa None Al-Hasani [26]: no effect
Varughese [43]: increased in the EG
b
Moderate
HRH
 1 Not Serious Not serious Not serious Not serious None No difference
High
PRP
 1 Not serious Not serious Not serious Not serious None Tehranchi [31]: no effect
El-Timamy [32]: no effect

High
Vit C
 1 Seriousa Not serious Not serious not serious None Increased in the EG b
Moderate
  1. EG experimental group, HRH human relaxin hormone, PRP platelet-rich plasma, Vit C vitamin C, Vit D vitamin D
  2. aThe results overall are based only on few studies
  3. bOwing to the lack of concealed allocation in the randomization, the respective grading of evidence started as moderate
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