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Table 2 Summary of the data from included studies

From: Allergies/asthma and root resorption: a systematic review

1. Authorship 2. Material 3. Exposure 4. Methodology 5. Results 6. Conclusions
Author, year
Study design
Risk factor/outcome
M/F (n)
Mean age ± SD (years)
Malocclusion (Mocl)
Orthodontic device
Mean treatment time of orthodontic treatment
± SD (years)
Asthma or allergies Evaluated teeth
Evaluation method
Incidence of root resorption (%)/prevalence of risk factors (%) Odds ratio (OR) (IC 95%)
p value
Control Exposed Control Exposed Control Exposed
McNab et al. [14], 1999
Retrospective cohort
Patients without asthma
38M/59F
13.9 ± 1.8 years
Patients with asthma
18M/26F
14.5 ± 3.2 years
Mocl: N.I
Fixed appliance, with or without headgear
1.9 ± 0.5 years
Mocl: NI
Fixed appliance, with or without headgear
1.8 ± 0.4 years
Asthma PM’s, mesio-buccal and disto-buccal roots of the upper 1st M, mesial and distal roots of the lower 1st M
Panoramic radiography
Sharpe scale
T0:
Severe OIIRR: 0.93%
T1:
Severe OIIRR: 15.27%
N. I
T0:
Severe OIIRR: 2.3%
T.1:
Severe OIIRR: 13.15%
N. I
OR=N.A
Multivariate analysis: p=0.019
- Although there is an association between root resorption and the asthma risk factor (p = 0.019), asthmatic and non-asthmatic individuals exhibited similar values of severe OIIRR.
Melo et al. [15], 2018
Case-control
Patients with initial OIIRR
300M/314F
14.37 ± 2.76 years
Patients with severe OIIRR
32M/37F
15.09 ± 3.44 years
Mocl:
Cl I=266
Cl II=319
Cl III=29
Fixed appliance
2.07 ± 0.93 years
Mocl:
Cl I=24
Cl II=43
Cl III=2
Fixed appliance
2.72 ± 1.07 years
Asthma Upper and lower incisors
Periapical radiography
Levander and Malmgren method
N.I
With asthma=35%
Without asthma= 65%
N.I
With asthma=36.2%
Without asthma=63.7%
OR= 1.05 (0.62-1.77)
p=0.94
-The prevalence of individuals with asthma was like the two groups.
-There was no association between the risk factor asthma and OIIRR (p = 0.841)
-Asthmatic and non-asthmatic individuals have the same chance of developing OIIRR (OR=1.05, 95% CI=0.62-1.77).
Nishioka et al. [11], 2006
Case-control
Patients without OIIRR
18M/42F
M: 15.9 ± 4.5 years
F: 18.5 ± 5.2 years
17.7 ± 5.1 years
Patients with OIIRR
18M/42F
M: 17.7 ± 5.7 years
F: 16.4 ± 6.0 years
16.8 ± 5.9 years
Mocl:
Cl I=10
Cl II=29
Cl III=21
Fixed appliance
2.96 ± 0.56 years
Mocl:
Cl I=10
Cl II=29
Cl III=21
Fixed appliance
3.10 ± 1.19 years
Allergies and asthma All teeth
Panoramic radiography, measured with a digital pachymeter
N.I
With allergies: 21%
With asthma: 5%
N.I
With allergies: 40%
With asthma: 15%
Allergy risk factor:
OR= 2.41 (1.08-5.37)
p=0.04
Asthma risk factor:
OR=3.35 (0.86-13.06)
p=0.12
-The prevalence of risk factors was higher in individuals with OIIRR.
- Allergic individuals are more likely to develop OIIRR than non-allergic individuals (OR = 2.41, 95% CI = 1.08-5.37).
-However, asthmatic, and non-asthmatic individuals have the same chance of developing OIIRR (OR=3.35, 95% CI=0.86-13.06).
Owman-Moll et al. [17], 2000
Case-control
Patients with initial OIIRR
25 (N.I.)
13.4 a ±N. I
Patients with severe OIIRR
25 (N.I.)
13.4 a ±N. I
Mocl:
N. I.
Fixed appliance and lower lingual arch
N. I
Mocl:
N. I.
Fixed appliance and lower lingual arch
N. I
Allergy Upper PM’s
Histological analysis
N.I
With allergies: 13.3%
N.I
With allergies: 26.6%
OR=1.17 (0.38-3.75)
p=1
- The prevalence of allergies was higher in individuals with severe OIIRR.
-However, allergic, and non-allergic individuals have the same chance of developing OIIRR (OR=1.17, 95% CI=0.38-3.75).
Pastro et al. [19], 2018
Case-control
Patients with initial OIIRR
252M/255F
14.21 ± 2.45 years
Patients with severe OIIRR
40M/53F
14.57 ± 2.67 years
Mocl:
Cl I=220
Cl II=269
Cl III=18
Fixed appliance
1.81 ± 0.83 years
Mocl:
Cl I=38
Cl II=52
Cl III=3
Fixed appliance
2.41 ± 0.99 years
Allergy Upper and lower incisors
Periapical radiography
Levander and Malmgren method
N.I
With allergies: 42%
Without allergy:58%
N.I
With allergies: 49.46%
Without allergy: 50.53%
OR=1.35 (0.86-2.1)
p=0.22
-The prevalence of allergies was higher in individuals with severe OIIRR.
-There was no association between the allergy risk factor and OIIRR (p = 0.182).
-Allergic and non-allergic individuals have the same chance of developing OIIRR (OR=1.35, 95% CI=0.86-2.1).
Shim et al. [16], 2003
Case-control
Patients without OIIRR
25M/26F
15.40 ± 4.10 years
Patients with OIIRR
25M/26F
16.10 ± 3.30 years
Mocl:
Cl I=15
Cl II=13
Cl III=23
Fixed appliance
2.31 ± 0.77 years
Mocl:
Cl I=15
Cl II=14
Cl III=22
Fixed appliance
2.13 ± 0.73 years
Allergy and asthma All teeth
Panoramic radiography
Measurement of root length on panoramic radiography
N.I
With allergies: 31%
With asthma: 5.88%
N.I
With allergies: 49%
With asthma: 17.64%
Allergy risk factor:
OR= 2.10 (0.93-4.71)
p=0.1
Asthma risk factor:
OR=3.42
(0.87-13.5)
p=0.12
-The prevalence of allergies was higher in individuals with OIIRR, but without statistical significance (OR=2.1, 95%CI= 0.93-4.71).
-The prevalence of asthma was statistically higher in individuals with OIIRR (p = 0.01).
-However, asthmatic individuals have the same chance of developing OIIRR as non-asthmatic individuals (OR = 3.42, 95%CI = 0.87-13.5).
  1. T0 before orthodontic treatment; T1 after orthodontic treatment; M molar; PM premolar, NI not informed; N.A not applied; SD standard deviation; M male; F female; OIIRR orthodontically induced inflammatory root resorption