Fig. 4

Histological analysis of the compression area in experimental groups (hematoxylin/eosin staining). Non-compressed PDL was observed in the control groups (A, B). Significant PDL compression was observed in orthodontically loaded groups (C, D). Note extensive PDL acellular areas in orthodontically loaded maxillae treated with IG9402 + OTM10-day (arrow) (D)