Table 4 Comparison of cfNA level (ng/μl) between successful and failed MSI and its ability to predict failed MSI
| Time |
Success (S) Mean ± SD Median (IQR) |
Failure (F) Mean ± SD Median (IQR) |
S − F Difference (95% CI) | P |
AUROC (%) (95% CI) | Cutoff |
Sensitivity (%) (95% CI) |
Specificity (%) (95% CI) |
PPV (%) (95% CI) |
NPV (%) (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|
| T1 |
0.4 ± 0.86 0.1 (0.02, 0.31) |
0.7 ± 0.36 0.8 (0.49, 1.02) |
−0.32 (−0.88, −0.24) | 0.05 |
79.0 (63.8, 94.2) | > 0.4 |
80 (44.4, 97.5) |
86.1 (70.5, 95.3) |
61.5 (31.6, 86.1) |
93.9 (79.8, 99.3) |
| T2 |
0.9 ± 0.72 0.7 (0.32, 1.02) |
1.1 ± 0.48 1.2 (0.71, 1.32) |
−0.26 (−0.75, 0.22) | 0.09 |
67.9 (51.5, 84.3) | > 1.1 |
60 (26.2, 87.8) |
77.8 (60.8, 89.9) |
42.9 (17.7, 71.1) |
87.5 (71.0, 96.5) |
| T3 |
0.2 ± 0.31 0.1 (0.03, 0.32) |
0.9 ± 0.30 0.9 (0.70, 1.06) |
−0.65 (−0.98, −0.32) | < 0.01 |
92.4 (82.0, 100.0) | ≥ 0.5 |
100 (39.8, 100.0) |
80.6 (64.0, 91.8) |
36.4 (10.9, 69.2) |
100.0 (88.1, 100.0) |
| T4 |
0.5 ± 0.53 0.3 (0.10, 0.62) | |||||||||
| T5 |
0.8 ± 0.70 0.7 (0.30, 0.90) | |||||||||
| T6 |
0.3 ± 0.36 0.2 (0.03, 0.53) | |||||||||
| T7 |
0.3 ± 0.35 0.1 (0.02, 0.31) | |||||||||
| T8 |
0.2 ± 0.24 0.04 (0.02, 0.20) |