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Progress in Orthodontics

Table 4 Comparison of cfNA level (ng/μl) between successful and failed MSI and its ability to predict failed MSI

From: Expression of circulating cell-free nucleic acids around miniscrew implant during orthodontic tooth movement—a prospective study

Time

Success (S)

Mean ± SD

Median (IQR)

Failure (F)

Mean ± SD

Median (IQR)

S − F

Difference

(95% CI)

P

AUROC (%)

(95% CI)

Cutoff

Sensitivity (%)

(95% CI)

Specificity (%)

(95% CI)

PPV (%)

(95% CI)

NPV (%)

(95% CI)

T1

0.4 ± 0.86

0.1 (0.02, 0.31)

0.7 ± 0.36

0.8 (0.49, 1.02)

−0.32

(−0.88, −0.24)

0.05

79.0

(63.8, 94.2)

> 0.4

80

(44.4, 97.5)

86.1

(70.5, 95.3)

61.5

(31.6, 86.1)

93.9

(79.8, 99.3)

T2

0.9 ± 0.72

0.7 (0.32, 1.02)

1.1 ± 0.48

1.2 (0.71, 1.32)

−0.26

(−0.75, 0.22)

0.09

67.9

(51.5, 84.3)

> 1.1

60

(26.2, 87.8)

77.8

(60.8, 89.9)

42.9

(17.7, 71.1)

87.5

(71.0, 96.5)

T3

0.2 ± 0.31

0.1 (0.03, 0.32)

0.9 ± 0.30

0.9 (0.70, 1.06)

−0.65

(−0.98, −0.32)

< 0.01

92.4

(82.0, 100.0)

≥ 0.5

100

(39.8, 100.0)

80.6

(64.0, 91.8)

36.4

(10.9, 69.2)

100.0

(88.1, 100.0)

T4

0.5 ± 0.53

0.3 (0.10, 0.62)

         

T5

0.8 ± 0.70

0.7 (0.30, 0.90)

         

T6

0.3 ± 0.36

0.2 (0.03, 0.53)

         

T7

0.3 ± 0.35

0.1 (0.02, 0.31)

         

T8

0.2 ± 0.24

0.04 (0.02, 0.20)

         
  1. IQR interquartile range, PPV positive predictive value, NPV negative predictive value, AUROC curve Area under the receiver operating characteristic curve
  2. P < 0.05 = statistically significant, P < 0.01 = statistically highly significant
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