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Table 4 Comparison of cfNA level (ng/μl) between successful and failed MSI and its ability to predict failed MSI

From: Expression of circulating cell-free nucleic acids around miniscrew implant during orthodontic tooth movement—a prospective study

Time Success (S)
Mean ± SD
Median (IQR)
Failure (F)
Mean ± SD
Median (IQR)
S − F
Difference
(95% CI)
P AUROC (%)
(95% CI)
Cutoff Sensitivity (%)
(95% CI)
Specificity (%)
(95% CI)
PPV (%)
(95% CI)
NPV (%)
(95% CI)
T1 0.4 ± 0.86
0.1 (0.02, 0.31)
0.7 ± 0.36
0.8 (0.49, 1.02)
−0.32
(−0.88, −0.24)
0.05 79.0
(63.8, 94.2)
> 0.4 80
(44.4, 97.5)
86.1
(70.5, 95.3)
61.5
(31.6, 86.1)
93.9
(79.8, 99.3)
T2 0.9 ± 0.72
0.7 (0.32, 1.02)
1.1 ± 0.48
1.2 (0.71, 1.32)
−0.26
(−0.75, 0.22)
0.09 67.9
(51.5, 84.3)
> 1.1 60
(26.2, 87.8)
77.8
(60.8, 89.9)
42.9
(17.7, 71.1)
87.5
(71.0, 96.5)
T3 0.2 ± 0.31
0.1 (0.03, 0.32)
0.9 ± 0.30
0.9 (0.70, 1.06)
−0.65
(−0.98, −0.32)
< 0.01 92.4
(82.0, 100.0)
≥ 0.5 100
(39.8, 100.0)
80.6
(64.0, 91.8)
36.4
(10.9, 69.2)
100.0
(88.1, 100.0)
T4 0.5 ± 0.53
0.3 (0.10, 0.62)
         
T5 0.8 ± 0.70
0.7 (0.30, 0.90)
         
T6 0.3 ± 0.36
0.2 (0.03, 0.53)
         
T7 0.3 ± 0.35
0.1 (0.02, 0.31)
         
T8 0.2 ± 0.24
0.04 (0.02, 0.20)
         
  1. IQR interquartile range, PPV positive predictive value, NPV negative predictive value, AUROC curve Area under the receiver operating characteristic curve
  2. P < 0.05 = statistically significant, P < 0.01 = statistically highly significant