Table 1 Dentin phosphoprotein biomarker levels in the two study groups at the different time points

Week 0

Mean ± SD

0.021 ± 0.009

0.020 ± 0.008

0.001 (0.01)

− 0.01, 0.01

0.78

Median (IQR)

0.021 (0.012, 0.030)

0.021 (0.011, 0.028)

Week 1

Mean ± SD

0.388 ± 0.007

0.383 ± 0.005

0.005 (0.006)

− 0.0007, 0.01

0.13

Median (IQR)

0.386 (0.383, 0.387)

0.383 (0.382, 0.385)

Week 3

Mean ± SD

0.384 ± 0.003

0.388 ± 0.005

− 0.004 (0.006)

− 0.009, 0.0009

0.08

Median (IQR)

0.383 (0.383, 0.385)

0.389 (0.387, 0.392)

Week 4

Mean ± SD

0.375 ± 0.002

0.299 ± 0.08

0.07 (0.08)

0.007, 0.14

0.04*

Median (IQR)

0.375 (0.374, 0.375)

0.294 (0.267, 0.368)

Week 5

Mean ± SD

0.385 ± 0.004

0.340 ± 0.07

0.04 (0.07)

− 0.01, 0.10

0.21

Median (IQR)

0.385 (0.382, 0.388)

0.367 (0.263, 0.394)

Week 8

Mean ± SD

0.391 ± 0.002

0.293 ± 0.09

0.10 (0.09)

0.02, 0.17

0.04*

Median (IQR)

0.391 (0.390, 0.392)

0.292 (0.202, 0.392)

Mean difference (week 8–0)

Mean ± SD

0.370 ± 0.01

0.273 ± 0.09

0.10 (0.09)

0.02, 0.18

0.04*

Median (IQR)

0.372 (0.360, 0.380)

0.271 (0.180, 0.373)

Friedman test

< 0.001*

< 0.001*