Skip to main content

Table 6 Summary of findings according to GRADE

From: The effectiveness of the early orthodontic correction of functional unilateral posterior crossbite in the mixed dentition period: a systematic review and meta-analysis

RME compared with untreated control group for treatment of functional posterior cross bite
Patient or population: patients in mixed dentition had functional posterior crossbite
Intervention: RME
Comparison: untreated control group
Outcomes Anticipated absolute effects* (95% CI) Relative effect (95% CI) № of participants (studies) Certainty of the evidence (GRADE) Comments
Risk with untreated control group Risk with RME
Maxillary intermolar width   MD 4.3 higher (2.05 higher to 6.55 higher) 66 (1 RCT) VERY LOWa,b RME may increase the maxillary intermolar width compared with control group but the evidence is very uncertain
Maxillary intercanine width   MD 2.6 higher (0.93 higher to 4.27 higher) 66 (1 RCT) VERY LOWa,b RME may increase the maxillary intercanine width compared with control group but the evidence is very uncertain
Mandibular intermolar width   MD 0 (1.51 lower to 1.51 higher) 66 (1 RCT) VERY LOWa,b,c The evidence is very uncertain about the effect of RME on mandibular intermolar width
Mandibular intercanine width   MD 0.8 higher (0.38 lower to 1.98 higher) 66 (1 RCT) VERY LOWa,b,d The evidence is very uncertain about the effect of RME on mandibular intercanine width
Mandibular midline correction   MD 1.8 lower (2.56 lower to 1.04 lower) 66 (1 RCT) VERY LOWa,b RME may reduce the mandibular midline deviation compared with control group but the evidence is very uncertain
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI)
CI: Confidence interval; MD: Mean difference
GRADE Working Group grades of evidence
High certainty: We are very confident that the true effect lies close to that of the estimate of the effect
Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect
Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect
  1. Explanations
  2. aHigh risk due to reporting bias
  3. bThe number of patients who provide data is low
  4. cThe boundaries of the CI are not on the same side of their decision-making threshold
  5. dhe recommendation will be altered if the lower versus the upper boundary of the CI represent the true underlying effect