Role of mechano-sensitive non-coding RNAs in bone remodeling of orthodontic tooth movement: recent advances

Yan, Lichao; Liao, Li; Su, Xiaoxia

doi:10.1186/s40510-022-00450-3

Progress in Orthodontics

Table 2 A summary of lncRNAs and their physiological effects on bone remodeling

From: Role of mechano-sensitive non-coding RNAs in bone remodeling of orthodontic tooth movement: recent advances

LncRNA	Major targets	Indirect targets and signaling pathway	Physiological effects	References
XIST	miR-214-3p	Unknown	Inhibit osteogenic differentiation of PDLSCs	[109]
	miR-29b-3p	RUNX2	Inhibit OB differentiation	[110]
	miR-135	RANKL	Inhibit OB differentiation	[111]
	miR-375-3p	AKT/mTOR	Inhibit OB differentiation	[112]
DANCR	Unknown	WNT	Promote osteogenic differentiation of PDLSC	[113]
	Unknown	EZH2↓, Runx2↑	Increase OB proliferation and decrease OB apoptosis	[114]
	miR-758	Notch2	Suppress osteogenic differentiation of PDLSC	[115]
	Jagged1	Notch	Facilitate osteoclast formation and root resorption	[116]
TUG1	miR-222-3p	Smad2/7	Facilitate osteogenic differentiation of PDLSC	[117]
	Unknown	Wnt/β-catenin	Promote OB proliferation and differentiation	[118]
	miR-545-3p	CNR2	Promote OB proliferation and differentiation	[119]
	miR-34a	FGFR1	Promote OB proliferation and inhibit apoptosis	[61]
	Unknown	MafB	Stimulate osteoclast formation	[120]
PCAT1	miR-106a-5p	BMP2	Promote osteogenic differentiation of PDLSC	[121]
H19	miR-675	TGF-β1/Smad3/HDAC	Promote osteogenic differentiation of hMSC	[122]
	miR-22, -141	Wnt/β-catenin	Potentiate osteogenesis	[123]
	miR-138	FAK	Unknown	[124]
	miR-188	LCoR	Promote osteogenic differentiation of mBMSC	[125]
	miR-19b-3p	Unknown	Promote cell proliferation and osteogenic differentiation of BMSCs	[126]
	miR-675	APC	Promote osteogenic differentiation of BMSC	[127]
	miR-149	SDF-1	Stimulates osteogenic differentiation of BMSC	[128]
	miR-185-5p	IGF1	Promote matrix mineralization	[129]
	miR-140-5p	SATB2	Promote osteogenic differentiation of BMSC	[130]
	miR-467	HoxA10	Promote osteogenic differentiation of BMSC	[131]
	miR-106	Angpt1	Promote osteogenesis and angiogenesis	[132]
	miR-625-5p	Wnt/β-catenin	Promote BMSC proliferation and osteogenic differentiation	[133]
	miR-541-3p	Wnt/β-catenin	Promote osteogenic differentiation of BMSC	[134]
	miR-532-3p	SIRT1	Promote osteogenic differentiation of BMSC	[135]
	miR-214-5p	BMP2	Promote osteogenic differentiation of BMSC	[136]
MALAT1	miR-143	Osterix	Promote osteogenic differentiation of BMSC	[137]
	miR-155-5p	ETS1	Promote osteogenic differentiation of PDLSC	[138]
SNHG1	miR-101	DKK1	Suppress osteoblast differentiation	[139]
	miR-181c-5p	SFRP1/Wnt/β-catenin	Inhibit OB differentiation and angiogenesis and promote OC formation	[140]
	KLF2	Unknown	Inhibit osteogenic differentiation of PDLSC	[141]
NEAT1	miR-7	PTK2	Stimulate osteoclastogenesis	[142]
MIRG	miR-1897	Unknown	Stimulate osteoclastogenesis and bone resorption	[143]

lncRNAs long non-coding RNAs, XIST X-inactive specific transcript, DANCR Differentiation antagonizing non-protein coding RNA, EZH2 Enhancer of zeste homolog 2, TUG1 Taurine upregulated 1, CNR2 cannabinoid receptor 2, MafB musculoaponeurotic fibrosarcoma oncogene homolog B, PCAT1 prostate cancer-associated ncRNA transcript 1, FAK Focal adhesion kinase, LCoR Ligand-dependent corepressor, SDF-1 Stromal Cell Derived Factor 1, IGF1 insulin-like growth factor 1, SATB2 Special AT-rich sequence-binding protein 2, HoxA10 homeobox A10, Angpt1 angiopoietin 1, SIRT1 sirtuin 1, MALAT1 metastasis-associated lung adenocarcinoma transcript 1, ETS1 E26 transformation specific-1, SNHG1 Small nucleolar RNA host gene 1, DKK1 Dickkopf-1, SFRP1 secreted frizzled-related protein 1, KLF2 Kruppel-like factor 2, NEAT1 nuclear paraspeckle assembly transcript 1

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