Table 2 Protocols of the ongoing studies registered at the clinical.trials.gov and the ANZCTR
Study ID | Trial name or title | Study design | Intervention + treatment comparison | Sample size/age/gender | Outcomes |
|---|---|---|---|---|---|
NCT02606331 | Efficacy of minimally invasive surgical technique in accelerating orthodontic treatment | -RCT/PG -Single blind (outcomes assessor) | -Piezocision + OT vs. OT - MOPs accomplished by ER: YAG laser + OT vs. OT | 36/15–27/both (male, females) | Primary outcomes: rate of canine retraction Secondary outcomes: rate of molar anchorage loss/canine rotation/levels of pain and discomfort |
NCT02359760 | Assessment of piezoelectric periodontal surgery effects on orthodontic treatment: a prospective pilot study | - RCT/PG -Single blind (outcomes assessor) | Piezocision + OT vs. OT | EXP:20, CON:40/18–40/both (male, females) | Primary outcomes: duration of orthodontic treatment Secondary outcomes: compare the duration of treatment with the control group/overall quality of treatment (ABO) standards/pain/inflammatory markers/density and bone volume/root resorption |
NCT02590835 | Efficiency of piezocision-assisted orthodontic treatment in adult patients | - RCT/PG -Open label | Piezocision + OT vs. OT | 24/21 years and older/both (male, females) | Primary outcomes: overall treatment time measurement. Secondary outcomes: root resorption/periodontal parameters/patient-centred outcomes |
NCT01720797 | Alveolar micro-perforation for inflammation-enhanced tooth movement during orthodontic treatment (propel) | - RCT/PG - Open label | MOPs + OT vs. OT | 15/18–55/both (male, females) | Primary outcomes: tooth movement Secondary outcomes: NR |
NCT02549950 | Efficiency of piezo-corticision in accelerating orthodontic tooth movement | - RCT/PG - Open label | Peizo-corticision + OT vs. OT | NR/15–35/both (male, females) | Primary outcomes: rate of orthodontic canine movement. Secondary outcomes: rate of orthodontic incisor retraction/quality of treatment outcome (ABO) standards |
NCT02473471 | Micro-osteoperforation and tooth movement | - RCT/PG -Double blind (investigator outcomes assessor) | MOPs + OT vs. OT | 40/13–45/both (males, females) | Primary outcomes: rate of tooth movement Secondary outcomes: pain/root resorption/patient satisfaction |
NCT02571348 | Optimum micro-osteoperforations accelerated tooth movement interval | -RCT/PG -Single blind (outcomes assessor) | MOPs + OT vs. OT | 36/18–45/both (males, females) | Primary outcomes: rate of orthodontic tooth movement Secondary outcomes: rate of orthodontic tooth movement between maxilla and mandible and when micro-osteoperforations performed at 4-, 8- and 12-week intervals/pain. |
NCT02416297 | Three-dimensional evaluation of accelerated tooth movement | - RCT/PG - Open label | MOPs + OT vs. OT | 50/16–60/both (males, females) | Primary outcomes: velocity rate of anterior retraction/bone demineralization Secondary outcomes: NR |
ACTRN12615000593538 Register: ANZCTR | The effects of micro-osteoperforations on orthodontic root resorption and tooth movement—a pilot study | -RCT/SP -Double blind (investigator, outcomes assessor) | MOPs + OT vs. OT | 15/12–18/both (males, Females) | Primary outcomes: root resorption Secondary outcomes: orthodontic tooth movement/level of discomfort |