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Progress in Orthodontics
Fig. 4 | Progress in Orthodontics

Fig. 4

From: Parathyroid hormone promotes maxillary expansion and reduces relapse in the repeated activation maxillary expansion rat model by regulating Wnt/β-catenin pathway

Fig. 4

PTH promoted bone remodeling and reduced relapse in the process of maxillary expansion. The rats were divided into control, PTH, expansion, expansion + PTH, expansion + relapse and expansion + relapse + PTH groups, respectively. A H&E staining was performed to evaluate the conditions of palatal suture tissue remodeling and widening. Magnification, 400 ×. B Toluidine blue staining was utilized to assess the changes of chondrocytes in each group. Magnification, 400 ×. C IHC assay was used to detect the new bone formation in each group. Magnification, 400 ×. D TRAP staining was used to assess the osteoclasts and bone resorption in each group. Magnification, 400 ×. The white arrow indicates osteoclast ,and the blue arrow indicates regenerated new bone. Based on the H&E staining results, the quantitative analysis of E chondrocytes, F osteoclasts, G osteoblasts was calculated in control, PTH, expansion, expansion + PTH, expansion + relapse and expansion + relapse + PTH groups. H The expression of collagen type I was counted based on the IHC results. I The relative optical density was counted according to the TRAP staining results. *P < 0.05, **P < 0.01 versus control group; #P < 0.05 versus expansion group; $P < 0.05 versus without PTH group. The red arrow indicates chondrocyte, the black arrow indicates osteoclast, and the blue arrow indicates osteoblast

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