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Progress in Orthodontics
Fig. 6 | Progress in Orthodontics

Fig. 6

From: Extracellular vesicles derived from M1 macrophages enhance rat midpalatal suture expansion by promoting initial bone turnover and inflammation

Fig. 6

Schematic illustration of the mechanism by which M1 sEVs enhance palatal suture expansion. M1 sEVs promote the early inflammatory state by increasing the content of RANKL and promoting the formation of osteoclasts, thus increasing the effect of bone turnover. They also promote the activation of the NF-κB signaling pathway in the palatal region by increasing the content of p65 protein

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