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Progress in Orthodontics
Fig. 5 | Progress in Orthodontics

Fig. 5

From: Angiotensin(1-7) attenuates tooth movement and regulates alveolar bone response during orthodontic force application in experimental animal model

Fig. 5

Real time PCR and analysis of genes expressions. A Relative expressions of targeted genes in different experimental groups at the pressure and tension sites after 5 and 14 days of orthodontic force application. Tumor necrosis factor alpha (TNF-α), hypoxia-inducible factor 1-alpha (HIF-1α), vascular endothelial growth factor (VEGF), alkaline phosphatase (ALP), osteocalcin (OC), cathepsin K (CTSK), tartrate-resistant acid phosphatase (TRAP), receptor activator of nuclear factor kappa-Β ligand (RANKL), osteoprotegerin (OPG), and RANKL/OPG ratio. B Heatmap showing the distribution of the means of the expressions of different genes from all groups at the early (5 days) and late (14 days) timepoints at the pressure and tension sites. Quantitative results are expressed as Mean ± SE (n = 6). Significant difference between groups is represented as (*P < 0.05, **P < 0.01, and ***P < 0.001). Significant difference between pressure and tension sites is represented as (#P < 0.05, # #P < 0.01, and # # #P < 0.001). Significant difference between timepoints within the same site and group is represented as similar lowercase letters (one letter indicates P < 0.05, two letters indicate P < 0.01, and three letters indicate P < 0.001)

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