The effect of the local administration of biological substances on the rate of orthodontic tooth movement: a systematic review of human studies

Progress in Orthodontics

Table 6 Quality of the available evidence on the rate of orthodontic tooth movement for the non-randomized trials

EG experimental group, PGE1 prostaglandin E1, PRF platelet-rich fibrin, Vit D3 vitamin D
^aThe results are based on few studies with small sample size
^bOwing to the non-randomized study design (prospective non-randomized trials), high risk of bias, the respective grading of evidence ranged between moderate and low. Possible serious risk because of the multitude of domains rated as unclear and the inconsistency in the measurement techniques to evaluate the rate of OTM