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Table 6 Quality of the available evidence on the rate of orthodontic tooth movement for the non-randomized trials

From: The effect of the local administration of biological substances on the rate of orthodontic tooth movement: a systematic review of human studies

Quality assessment Effect Quality
Studies Risk of bias Inconsistency Indirectness Imprecision Other
PGE1
 3 Seriousa Not serious Not serious Not serious None Increase in the EG b
Moderate
Vit D
 1 Seriousa Serious Not serious Not serious None Increased in EG b
Low
PRF
 1 Not serious Not serious Not serious Serious None Increased in EG b
Moderate
  1. EG experimental group, PGE1 prostaglandin E1, PRF platelet-rich fibrin, Vit D3 vitamin D
  2. aThe results are based on few studies with small sample size
  3. bOwing to the non-randomized study design (prospective non-randomized trials), high risk of bias, the respective grading of evidence ranged between moderate and low. Possible serious risk because of the multitude of domains rated as unclear and the inconsistency in the measurement techniques to evaluate the rate of OTM
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